What are the side effects of sulindac

what are the side effects of sulindac

Phenylbutazone

Nov 03,  · Sulindac side effects. Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Get emergency medical help if you have signs of a heart attack or stroke: chest. Sulindac (Clinoril), is a drug used for the treatment of inflammation and pain that results from rheumatoid arthritis, tendinitis, bursitis, ankylosing spondylitis, gout, osteoarthritis. Learn about uses, complications and side effects for sulindac.

Medically reviewed by Drugs. Written by Cerner Multum. Sulindac is used to treat pain or inflammation caused by arthritis, ankylosing spondylitistendinitis, bursitisor gout. Sulindac can increase your risk of fatal heart attack or stroke. Do not use sulindac just supindac or after heart bypass surgery coronary artery bypass graft, or CABG.

Sulindac may also cause stomach or intestinal bleeding, which can be fatal. Sulindac wide increase your risk of fatal heart attack or stroke, even if you sdie have any effets factors. Do not use this medicine how to make onion raita for biryani before or after heart bypass surgery coronary artery bypass graft, or CABG.

These conditions can occur without warning while you are using sulindac, especially in older adults. You should not use sulindac if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. If you are pregnant, you should not take sulindac unless your doctor tells you to. Taking an NSAID during the how to make butterfly treat bags 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn sulindsc and possible complications with your pregnancy.

Follow all directions on your prescription label and read all medication guides. Your doctor may occasionally change your eide. Use the lowest dose that is effective in treating your condition.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your sid dose.

Do not take two doses at one time. They may contain ingredients similar to sulindac such as aspirin, ibuprofenketoprofenor naproxen.

Get emergency medical help if you have signs of an allergic reaction hivessneezing, runny nosewheezing, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throatburning eyes, skin pain, red or purple skin rash with blistering and peeling. Get emergency medical help if you have signs of a wat attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Ask your doctor ae using sulindac if you take an antidepressant.

This list is not complete. Other drugs may affect sulindac, including prescription and over-the-counter medicines, vitaminsand herbal products. Not all possible drug interactions are listed here. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Detailed Sulindac dosage information. Sulindac side effects more detail. Sulindac drug interactions more detail. Drug Status Availability Prescription only Rx. Mylan Pharmaceuticals Inc.

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Jun 28,  · Sulindac oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with sulindac . Apr 11,  · SIDE EFFECTS. The following adverse reactions were reported in clinical trials or have been reported since the drug was marketed. The probability exists of a causal relationship between CLINORIL (sulindac) and these adverse reactions. Jun 18,  · Side effects not requiring immediate medical attention. Some side effects of enalapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Phenylbutazone , often referred to as " bute ", [1] is a nonsteroidal anti-inflammatory drug NSAID for the short-term treatment of pain and fever in animals. In the United States and United Kingdom it is no longer approved for human use except in the United Kingdom for ankylosing spondylitis , as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the meat adulteration scandal.

Positive phenylbutazone tests in horse meat were uncommon in the UK, however. Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in However, it is no longer approved, and therefore not marketed, for any human use in the United States.

In the Kentucky Derby , Dancer's Image , the winner of the race, was disqualified after traces of phenylbutazone were allegedly discovered in a post-race urinalysis.

Owned by prominent Massachusetts businessman Peter D. Fuller and ridden by jockey Bobby Ussery , Dancer's Image was the first horse to win the Kentucky Derby and then be disqualified. Phenylbutazone was legal on most tracks around the United States in , but had not yet been approved by Churchill Downs. Controversy and speculation still surround the incident.

In the weeks prior to the race, Fuller had given previous winnings to Coretta Scott King , the widow of slain civil rights activist Martin Luther King Jr. The previous year, King held a sit-in against housing discrimination which disrupted Derby week.

Forty years later, Fuller still believed Dancer's Image was disqualified due to these events. Although Forward Pass had been named the winner, after many appeals the Kentucky Derby official website lists both Dancer's Image and Forward Pass as the winner. The website's race video commentary states that on the winner's plaque at Churchill Downs , both Dancer's Image and Forward Pass are listed as the winner of the Kentucky Derby. Phenylbutazone is occasionally used in dogs for the longer-term management of chronic pain, particularly due to osteoarthritis.

Gastrointestinal-protectant drugs, such as misoprostol , cimetidine , omeprazole , ranitidine , or sucralfate , are frequently included as a part of treatment with any NSAID. Dogs receiving chronic phenylbutazone therapy should be followed with regular blood work and renal monitoring.

Side effects of phenylbutazone in dogs include gastrointestinal GI ulceration, bone marrow depression, rashes, malaise, blood dyscrasias, and diminished renal blood flow.

Phenylbutazone has a plasma elimination half-life of 4—8 hours, however the inflammatory exudate half life is 24 hours, [10] so single daily dosing can be sufficient, although it is often used twice per day. Phenylbutazone can be administered orally via paste, powder or feed-in or intravenously. It should not be given intramuscularly or injected in any place other than a vein , as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein.

Overdose or prolonged use can cause gastrointestinal ulcers , blood dyscrasia , kidney damage primarily dose-dependant renal papillary necrosis , oral lesions if given by mouth, and internal hemorrhage. Phenylbutazone can also cause agranulocytosis.

Phenylbutazone amplifies the anticoagulant effect of vitamin K antagonists such as warfarin or phenprocoumon. Phenylbutazone displaces warfarin from plasma binding sites, and toxic blood levels leading to haemorrhage can occur. It may aggravate kidney or liver problems.

Phenylbutazone may be toxic to the embryo and can be transferred via the umbilical cord and by milk. Phenylbutazone can be used in foals. Premature foals, septicemic foals, foals with questionable kidney or liver function and foals with diarrhea require careful monitoring. Drugs to protect the GI tract such as omeprazole, cimetidine, and sucralfate are frequently used with phenylbutazone. High doses of phenylbutazone may be considered a rules violation under some equestrian organizations, as the drug may remain in the bloodstream four to five days after administration.

Use in horses is limited to those not intended for food. Metabolites of phenylbutazone can cause aplastic anaemia in humans.

Opinions are conflicting regarding the carcinogenicity of phenylbutazone in animals; no evidence indicates it causes cancer in humans at therapeutic doses. Maekawa et al. Other anti-inflammatory drugs that tend to cause GI ulcers, such as corticosteroids and other NSAIDs, can potentiate the bleeding risk. Combination with anticoagulant drugs, particularly coumarin derivatives, also increases the risk of bleeding. Avoid combining with other hepatotoxic drugs.

Phenylbutazone may affect blood levels and duration of action of phenytoin , valproic acid , sulfonamides , sulfonylurea antidiabetic agents, barbiturates , promethazine , rifampicin , chlorpheniramine , diphenhydramine , and penicillin G.

Overdoses of phenylbutazone can cause kidney failure , liver injury, bone marrow suppression , and gastric ulceration or perforation. Early signs of toxicity include loss of appetite , and depression. Phenylbutazone is a crystalline substance. It is obtained by condensation of diethyl n -butylmalonate with hydrazobenzene in the presence of base. In effect, this represents the formation of the heterocyclic system by simple lactamization.

Oxyphenbutazone , the major metabolite of phenylbutazone, differs only in the para location of one of its phenyl groups , where a hydrogen atom is replaced by a hydroxyl group making it 4-butyl 4-hydroxyphenyl phenyl-3,5-pyrazolidinedione. From Wikipedia, the free encyclopedia. This article needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can.

Unsourced or poorly sourced material may be challenged and removed. IUPAC name. DB Y. D Y. Interactive image. The New York Times. Advice for consumers". Enforcement and regulation. Food Standards Agency. Retrieved 19 May Food and Drug Administration.

Nonsteroidal Anti-Inflammatory Drugs. AAEP 47 : Archived from the original on Retrieved Journal of Veterinary Pharmacology and Therapeutics. PMID Journal of the American Veterinary Medical Association. American Journal of Veterinary Research.

Clinical pharmacology in therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Vet J ;— Irish Veterinary Journal. Archived from the original PDF on Canadian Food Inspection Agency. September Journal of the National Cancer Institute. Japanese Journal of Cancer Research. PMC Environmental Health Perspectives. Mutation Research. IARC monographs on the evaluation of the carcinogenic risk of chemicals to man. International Agency for Research on Cancer.

Wedgewood Pharmacy. Items listed in bold indicate initially developed compounds of specific groups. Topical products for joint and muscular pain M Clofezone Mofebutazone Oxyphenbutazone Phenylbutazone.

Diclofenac Fentiazac Tolmetin. Dimethyl sulfoxide Idrocilamide Tolazoline. Hidden categories: Webarchive template wayback links CS1: long volume value Articles needing additional medical references from November All articles needing additional references Articles requiring reliable medical sources Drugs with non-standard legal status ECHA InfoCard ID from Wikidata Drugboxes which contain changes to watched fields.

Namespaces Article Talk. Views Read Edit View history. Help Learn to edit Community portal Recent changes Upload file. Download as PDF Printable version. Wikimedia Commons. Pyrazolidines Clofezone Mofebutazone Oxyphenbutazone Phenylbutazone.



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