Co-amoxiclav (Augmentin) an antibiotic to treat bacterial infections
Nov 23, †Ј About co-amoxiclav Co-amoxiclav is given to treat bacterial infections. It is prescribed for sinus infections, urine infections, skin infections, joint infections and some dental infections. It is also given before some surgical operations, to prevent an infection from developing. May 07, †Ј Co-amoxiclav is used to treat infections caused by bacteria, such as: Chest infections, eg bronchitis, pneumonia, exacerbations of COPD. Ear, Occupation: Helen Marshall, Bpharm, Mrpharms.
It is likely one of the mostly prescribed antibiotics for kids, ceaselessly disbursed for ear infections. Antibiotics work by attacking the cell wall of micro organism which can be harming the physique, or they stop the micro organism from replicating. The drug is a mixture of two lively substances: amoxicillin and clavulanic acid. Collectively, the medication battle micro organism that may ordinarily be resistant to amoxicillin alone.
The antibiotic will also be used on animals. Ruminants, swine, horses, canine, cats and poultry are sometimes prescribed Augmentin for varied illnesses.
Augmentin is often taken orally, in tablet type for adults, and in a liquid usually flavored suspension for little kids. Docs prescribe the drug so actually because it really works in opposition to many sorts of disease-causing micro organism.
Alasdair Geddes, an emeritus professor of infectious illnesses on the College of Birmingham in England, who ran a number of the first scientific trials of Augmentin. The drug can be a robust agent in opposition to bronchitis and tonsillitis attributable to micro organism although many circumstances of sore throat are viral in origin. As well as, the drug can battle pneumonia, urinary tract infections, how to use forms in google docs and pores and skin infections.
The drug has additionally been seen as a great potential candidate for therapy of Lyme illness, chlamydia, sinusitis, gastritis and peptic ulcers, in accordance to a examine within the Worldwide Journal of Pharmacy and Pharmaceutical Sciences. The Mayo Clinic additionally lists amoxicillin as a protected antibiotic for being pregnant. The Meals and Drug Administration classifies Augmentin as a category B drug, which means there is no such thing as a proof for hurt.
The most typical unwanted side effects for Augmentin are nausea, upset abdomen, fuel and diarrhea. Largely, it is because clavulanic acid can irritate the intestine, Geddes mentioned.
Augmentin what is co- amoxiclav used to treat also go away individuals extra inclined to yeast infections Ч once more, as a result of it wipes out good bacterial populations that usually inhibit the expansion of yeast. People who find themselves allergic to penicillin-like medication are sometimes allergic to What is can in networking as properly, as a result of it comprises amoxicillin.
To check for this drug allergy, medical doctors can do a skin-prick check known as PrePen. In some situations, an allergy to Augmentin can lead to anaphylaxis, a lethal allergic response that may trigger the narrowing of the airways, the swelling of the lips and tongue, and a lethal drop in blood strain. Not often, the drug could cause issues with how the liver capabilities, which is able to lead to yellowing of the pores and skin known as jaundice.
And some remoted circumstances of youngsters reacting negatively to how to add music to psp from computer clavulanic acid in Augmentin have additionally been reported.
As an example, 10 kids who examined damaging for penicillin allergy, broke out into hives after taking Augmentin, in accordance to a examine within the journal Allergologia and Immunopathologia.
People gained their first highly effective weapon within the conflict in opposition to micro organism within the Nineteen Twenties. Although penicillin labored wonders, it had some unwanted side effects and was not efficient in opposition to all that many micro organism.
So, within the Fifties, scientists at Beecham Analysis Laboratories, which was created by the identical firm that produced Lucozade delicate drinks and Brylcreem hair gel, started creating new antibiotics. Their technique was easy and intelligent: they used the core chemical construction of penicillin, however added totally different facet chains to it, Geddes mentioned.
One in every of their early profitable medication was amoxicillin, an in depth relative to penicillin. Each amoxicillin and different penicillins have a key molecular construction that helps the kill micro organism: a chemical ring known as a beta-lactam.
Beta-lactam rings bind to enzymes in bacterial cell membranes. These enzymes are chargeable for cross-linking peptidoglycans, the constructing blocks used to type the bacterial cell wall.
When medication like amoxicillin disable these membrane enzymes, they stop the micro organism from increase the cell wall, even because the micro organism proceed to break down their previous cell wall. The micro organism die because of this. Amoxicillin was seen as a breakthrough as a result of it was absorbed higher than earlier antibiotics, had fewer of the unwanted side effects of antibiotics resembling methicillin, and appeared to work in opposition to a broad class of micro organism.
Nevertheless, it had one flaw: not less than some resistant populations of micro organism had advanced an capability to battle amoxicillin and different antibiotics by making an enzyme known as beta-lactamase, which primarily snipped the beta lactam ring open and disabled it.
Nevertheless, when mixed with amoxicillin, it created an outstanding antibiotic. Clavulanic acid was the final word decoy: when micro organism despatched out its antibiotic-snipping enzyme, Beta-lactamase, it could bind to clavulanic acid as a substitute.
As soon as certain, clavulanic acid modified its form and completely deactivated Beta-lactamase. Clavulanic acid labored extraordinarily properly in opposition to a number of lethal micro organism, together with Escherichia coliKlebisella aerogensPseudomonas aeruginosa and Staphylococcus aureusin accordance to a article within the journal of the American Society for Microbiology.
Augmentin este un agent antibiotic cu un spectru de activitate deosebit de larg, impotriva agentilor bacterieni patogeni intalniti de obicei in practica medicala generala si in spital. Activitatea inhibitorie a clavulanatului de potasiu asupra beta-lactamazelor extinde spectrul amoxicilinei la o gama larga de microorganisme, inclusiv la multe dintre cele rezistente la alte antibiotice beta-lactamice.
Indicatii terapeutice: Preparatele de Augmentin oral sunt point out in tratamentul de scurta durata al infectiilor bacteriene cu urmatoarele localizari: Infectii ale tractului respirator superior inclusiv nas, gat si urechi : de exemplu, amigdalite, sinuzite, otite medii; Infectii ale tractului respirator inferior: de exemplu, bronsite acute si cronice, pneumonie lobara, bronhopneumonie; Infectii ale tractului genito-urinar: de exemplu, cistite, uretrite, pielonefrite, gonoree; Infectii ale pielii si tesuturilor moi; Infectii osteo-articulare; Infectii dentare: de exemplu, abcese alveolodentare; Alte infectii: de exemplu, avort septic, infectii puerperale, infectii intraabdominale.
Desi Augmentin este indicat doar in situatiile de mai sus, orice infectie produsa de microorganisme sensibile la amoxicilina poate fi tratata cu Augmentin.
De aceea, infectii mixte cu microorganisme sensibile la amoxicilina si microorganisme producatoare de beta-lactamaza si sensibile la Augmentin pot sa nu necesite adaugarea altui antibiotic. Augmentin este bactericid pentru un numar mare de microorganisme incluzand: Germeni grampozitivi: Aerobi: Streptococcus faecalis, Streptococcus pyogenes, Staphylococcus aureus; Stafilococi coagulazo-negativi inclusiv Staphylococcus epidermidisBacillus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Corynebacterium spp, Listeria monocytogenes; Anaerobi: Clostridium spp.
Posologie si mod de administrare : Dozele utilizate in tratamentul infectiilor: Adulti si copii peste 12 ani: un comprimat de mg de 2 ori pe zi in tratamentul infectiilor usoare si medii, fara potential de evolutie severa. In infectiile extreme, cate un comprimat de 1 g de 2 ori pe zi. Terapia poate fi inceputa parenteral si continuata cu preparate orale. Mai jos se prezinta indicatiile de dozare pentru copii. Comprimatele de Augmentin de mg sau de 1 g what are the top 100 girl names of 2011 sunt recomandate copiilor in varsta de 12 ani sau mai how to make a 3d model of the circulatory system. Posologia in infectiile dentare de exemplu: abcese alveolodentare : Adulti si copii de peste 12 ani: se administreaza un comprimat de Augmentin de mg de doua ori pe zi, timp de cinci zile.
Comprimatele de 1 g nu sunt recomandate. Posologia in afectiuni hepatice: Se va administra cu prudenta; se va monitoriza functia hepatica la intervale regulate. Fiecare comprimat de mg Augmentin contine 0,63 mmoli 25 mg de potasiu. Mod de administrare : Oral: comprimate sau sirop. Pentru evitarea aparitiei intolerantei gastrointestinale, Augmentin se va administra imediat inainte de masa. Absorbtia Augmentinului este favorizata atunci cand acesta se administreaza la inceputul mesei.
Pentru prepararea siropului, preliminary agitati flaconul cu pulbere. Se lasa apoi 5 minute pentru a asigura dizolvarea totala a pulberii. Odata dizolvat, Augmentin sirop trebuie pastrat in frigider si utilizat intr-un interval de cel mult 7 zile. Se agita bine flaconul inaintea fiecarei administrari. Tratamentul cu Augmentin nu trebuie prelungit peste 14 zile fara avizul medicului. Contraindicatii: Hipersensibilitate la beta-lactamine, de exemplu peniciline si cefalosporine.
Precautii : La unii pacienti care au urmat tratament cu Augmentin s-au observat modificari ale testelor functionale hepatice. Semnificatia clinica a acestor modificari nu este certa, dar Augmentin trebuie utilizat cu atentie la pacientii care prezinta disfunctii hepatice evidente extreme. Icterul colestatic a fost rar semnalat, fiind de regula reversibil, uneori si sever.
Semnele si simptomele pot sa nu devina evidente how to calculate z value in excel perioada de pana la 6 saptamani de la intreruperea tratamentului. La pacientii cu afectiuni renale average sau extreme, dozele de Augmentin trebuie ajustate conform recomandarilor de la Posologie. La pacientii cu penicilino-terapie s-au inregistrat ocazional cazuri extreme sau fatale de reactii de hipersensibilitate anafilaxie.
Aceste reactii apar cu precadere la indivizii care au prezentat in antecedente hipersensibilitate la penicilina. Daca apare o reactie alergica, tratamentul cu Augmentin trebuie intrerupt si instituit un tratament alternativ adecvat. Reactiile anafilactice serioase necesita un tratament de urgenta cu adrenalina.
De asemenea, ar putea necesita oxigenoterapie, administrare intravenoasa de steroizi si reanimare respiratorie pana la intubatie. La pacientii care au primit amoxicilina rash-ul eritematos a fost asociat cu mononucleoza infectioasa. Administrarea prelungita poate duce, de asemenea, la cresterea microorganismelor rezistente.
Suspensia de Augmentin contine 12,5 mg de aspartam per doza de 5 ml si de aceea trebuie administrat cu prudenta in fenilcetonurie. Utilizarea in timpul sarcinii what is the difference between wheat germ and wheat bran alaptarii: Studiile de reproducere la animale soareci si sobolani carora li s-a administrat Augmentin nu au evidentiat efecte teratogene.
Exista o experienta limitata in ceea ce priveste utilizarea de Augmentin in timpul sarcinii. Ca si in cazul tuturor medicamentelor, terapia cu Augmentin in timpul sarcinii trebuie evitata, in particular in primul trimestru de sarcina, utilizandu-se numai atunci cand medicul considera administrarea absolut necesara.
Augmentin poate fi administrat in perioada alaptarii. Cu exceptia riscului de sensibilizare, asociat cu o excretie in cantitate mica in laptele matern, nu au fost remarcate efecte damaging asupra copilului alaptat. Interactiuni medicamentoase : La unii pacienti tratati cu Augmentin s-a constatat o prelungire a timpului de protrombina si a timpului de sangerare.
Augmentin trebuie utilizat cu atentie la pacientii care urmeaza un tratament cu anticoagulante. Nu se recomanda administrarea concomitenta de probenecid. Probenecidul scade secretia tubulara renala a amoxicilinei. Utilizarea concomitenta cu Augmentin poate duce la mentinerea unui nivel sangvin crescut al amoxicilinei, dar nu si a acidului clavulanic.
Administrarea concomitenta a alopurinolului si ampicilinei creste semnificativ incidenta rash-ului la pacientii care urmeaza tratament cu ambele medicamente, comparativ cu pacientii care urmeaza tratament doar cu ampicilina.
In orice caz, este cunoscut faptul ca posibilitatea aparitiei rash-ului la ampicilina este datorata alopurinolului. Nu exista date referitoare la administrarea concomitenta de Augmentin si alopurinol. Ca si in cazul altor antibiotice cu spectru larg, Augmentin poate cut back eficienta contraceptivelor orale si pacientii trebuie avertizati asupra acestui side.
Efecte hostile: Efectele hostile, ca si la amoxicilina, sunt uncommon si in majoritate tranzitorii si de intensitate mica. Au fost raportate diaree, indigestie, greturi, varsaturi, colite pseudomembranoase si candidoze intestinale. Greata, de altfel rara, este mai frecvent asociata cu dozele orale crescute.
Daca efectele hostile gastrointestinale apar la terapia orala, ele pot fi reduse prin administrarea de Augmentin la inceputul meselor. Rar in cursul tratamentului cu Augmentin s-au semnalat hepatite si ictere colestatice. Ele pot fi extreme si se pot mentine cateva luni.
Au fost raportate ca aparand predominant la adulti sau varstnici si usor mai frecvent la barbati. Semnele si simptomele pot aparea in timpul tratamentului, dar sunt mai frecvent intalnite dupa intreruperea acestuia pana la o perioada de 6 saptamani.
Reactiile hepatice sunt de regula reversibile.
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Amoxicillin is an antibiotic. Antibiotics are used to treat infections caused by bacteria. Co-amoxiclav is used in adults and children to treat the following infections: Х middle ear and sinus infections Х respiratory tract infections Х urinary tract infections Х skin and soft tissue infections including dental infections Х bone and joint infections. 2. What you need to know before you take Co-amoxiclav Do not take Co. Co-Amoxiclav is whatТs known as a broad-spectrum antibiotic. Antibiotics are used to treat all kinds of bacterial infections. Broad-spectrum means that these types of antibiotics can be used to help target a wide range of different infections. A doctor may prescribe these particular antibiotics in specific infections.
Co-amoxiclav, also known by its brand name Augmentin, is a combination antibiotic used to treat common bacterial infections. It comes in tablet and liquid form, or may be given by injection in hospital. Find out more about what co-amoxiclav is used for, dosage and possible side effects:. Co-amoxiclav is a mixture of amoxicillin , an antibiotic related to penicillin, with clavulanic acid, a medicine that makes amoxicillin more effective. Co-amoxiclav is used to treat common infections like chest infections, sinus infections, skin infections and urine infections UTIs , when these are caused by bacteria that are resistant to amoxicillin.
Co-amoxiclav comes as tablets and liquid and may also be given by injection in hospital. Augmentin is a brand name for co-amoxiclav. Co-amoxiclav is used to treat infections caused by bacteria , such as:. Co-amoxiclav is also given to prevent infections following surgery, particularly gastrointestinal, biliary tract, pelvic, major head and neck surgery and after limb amputation.
The amoxicillin part of co-amoxiclav works by interfering with the ability of bacteria to form cell walls.
It allows holes to appear in the bacterial cell walls and this kills the bacteria causing the infection. Some types of bacteria have become resistant to penicillin-type antibiotics, because they have developed the ability to produce defensive chemicals called beta-lactamases that stop the antibiotics from working. The clavulanic acid part of co-amoxiclav is a beta-lactamase inhibitor. It stops bacteria from inactivating the amoxicillin, so increases the range of bacteria that amoxicillin can kill.
Co-amoxiclav is a broad-spectrum antibiotic, which means it can treat infections caused by a wide variety of bacteria. However, it does not kill viruses and will not work to treat viral infections, such as colds, flu and most coughs and sore throats.
It's usually reserved for treating infections caused by bacteria that are resistant to amoxicillin. To make sure the bacteria causing an infection are susceptible to co-amoxiclav, your doctor may take a tissue sample , for example a swab from the throat or skin, or a urine or blood sample.
Co-amoxiclav is suitable for adults, including pregnant and breastfeeding women, and children of all ages. It can be taken by most people but is not suitable for:. Some people might need a lower co-amoxiclav dose or extra monitoring. Make sure your doctor knows if you:.
The manufacturers advise avoiding co-amoxiclav during pregnancy unless its use is essential. There may be an increased risk of a serious bowel condition called necrotising enterocolitis in newborn babies whose mothers have used co-amoxiclav. As with all medicines, it's important to make sure your doctor knows if you are pregnant before you start treatment. Co-amoxiclav is used to treat infections in babies and it can be used by women who are breastfeeding.
However, as with all medicines, make sure your doctor knows if you are breastfeeding before you start treatment with this antibiotic. Co-amoxiclav passes into breast milk in small amounts.
Although this is unlikely to have any harmful effects on a nursing infant, it could theoretically affect the natural bacteria found in the baby's mouth or gut. Let your doctor know if your baby develops diarrhoea or oral thrush while you're taking a course of co-amoxiclav. The dose of co-amoxiclav that's prescribed and how long you need to take it for depends on what infection is being treated, age, weight and kidney function.
Always follow the instructions given by your doctor. These will be printed on the label that your pharmacist has put on the packet of medicine. If you forget to take a dose at the correct time you should take it as soon as you remember, and then space the rest of the day's doses over the remainder of the day. Don't take a double dose to make up for a missed dose. To treat an infection your doctor may prescribe you a course of co-amoxiclav that lasts between 5 and 14 days.
Unless your doctor tells you otherwise, it is important that you finish the prescribed course of co-amoxiclav, even if you feel better or it seems the infection has cleared up. Stopping the course early makes it more likely that your infection will come back, or that the bacteria will grow resistant to the antibiotic. Make sure the medicine is out of the reach of children. The medicine keeps for 7 days; if there's any left after this you should dispose of it, preferably by returning it to your pharmacist.
Don't pour it down the sink. It's usually fine - there is no 'do not drink alcohol' warning that applies to taking co-amoxiclav because it doesn't specifically affect the medicine itself. However, if you feel unwell with your infection, or if you find co-amoxiclav gives you an upset stomach, then drinking alcohol could make this worse.
It's also possible that drinking excessive amounts of alcohol with co-amoxiclav could increase the risk of getting side effects on your liver. Co-amoxiclav side effects range from common to very rare. The following are some of the side effects that may be associated with co-amoxiclav. Just because a side effect is stated here doesn't mean that all people taking co-amoxiclav will experience that or any side effect. Medicines affect people in different ways. Common side effects affect between 1 in 10 and 1 in people.
Rare side effects affect between 1 in and 1 in 10, people. Read the leaflet that comes with your medicines or talk to your doctor or pharmacist if you want any more information about the possible side effects of co-amoxiclav. If you think you have experienced a side effect, did you know you can report this using the yellow card website?
Tell your doctor or pharmacist if you're already taking any medicines, including those bought without a prescription and herbal medicines, before you start treatment with co-amoxiclav. Similarly, check with your doctor or pharmacist before taking any new medicines while taking co-amoxiclav, to make sure that the combination is safe.
Some key points are:. If you need to ease pain or lower a high temperature fever it's fine to take over-the-counter painkillers such as paracetamol or ibuprofen while you're taking co-amoxiclav, assuming these are appropriate for you. Co-amoxiclav doesn't affect hormonal contraceptives such as the pill. However, if you experience vomiting or diarrhoea while taking this antibiotic, this can potentially make your pill less effective at preventing pregnancy.
If this happens to you, follow the instructions for vomiting and diarrhoea described in the leaflet provided with your pills. Co-amoxiclav may rarely alter the anti-blood-clotting effects of warfarin.
Your doctor may want to do extra tests of your blood clotting time INR if you are taking both medicines. Co-amoxiclav may decrease the removal of the medicine methotrexate from the body, which could increase the risk of its side effects. If you're taking methotrexate, your doctor may want to perform some extra checks while you are taking a course of this antibiotic.
Let your doctor know if you think you have experienced any new or increased side effects after starting this antibiotic. The oral typhoid vaccine Vivotif should not be taken until at least three days after you have finished a course of co-amoxiclav, because the antibiotic could make this vaccine less effective. Last updated: Parenting Mental health Healthy eating Conditions Follow. Type keyword s to search. Tijana87 Getty Images. Find out more about what co-amoxiclav is used for, dosage and possible side effects: What is co-amoxiclav?
What is co-amoxiclav used for? Co-amoxiclav is used to treat infections caused by bacteria , such as: Chest infections, eg bronchitis , pneumonia , exacerbations of COPD.
Ear, nose or throat infections, eg otitis media , sinusitis , tonsillitis. Urine infections , cystitis , kidney infections Skin and soft tissue infections, eg cellulitis , animal bites. Dental abscesses. Bone or joint infections, eg osteomyelitis.
Genital infections, including those following childbirth or abortion. Abdominal infections, eg peritonitis. Related Story. This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses.
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